BSC412/L/BSC512/L Medical Entomology
BSC410/L/512/L Human Parasitology
BSC453/553 Invertebrate Physiology
BSC478/L/578/L Methods in Biotechnology
BSC491/L/591/L Introduction to Bioinformatics
BSC497 Senior Practicum
Tick-borne diseases are an international public health concern, as more than 20 emerging and resurging pathogens of significant human diseases are vectored by tick species. These pathogens infect and multiply in several organs within the tick, in particular the salivary glands, which enable the infection to easily travel into vertebrate hosts during feeding. Our principal objective is to gain perspective on the tick-host interaction by examining the part played by the salivary ‘potion’ in maintaining the secure attachment and providing a suitable environment for tick-borne pathogens. The current goal of my ongoing research is to elucidate the molecular mechanism of tick salivary proteins in prolonged feeding on the host and vector competence using a combination of molecular, biochemical, physiological, and reverse genetic approaches. Better understanding of tick-pathogen-host interaction will aid in the development of control strategies for tick-transmitted diseases.
Current Graduate Students
Virginia Caroline Meyers
Budachetri K, Karim S. (2015). An insight into the functional role of Thioredoxin reductase, a selenoprotein, in maintaining normal native microbiota in the Gulf-Coast tick (Amblyomma maculatum). Insect molecular biology [doi: 10.1111/imb.12184]
Karim S, Ribeiro JM. (2015). An insight into the sialome of the Lone Star Tick, Amblyomma americanum, with a glimpse on its time dependent gene expression. PLoS One.10 (7):e0131292.
Budachetri K, Browning RE, Adamson SW, Dowd SE, Chao CC, Ching WM, Karim S. (2014). An insight into the microbiome of the Amblyomma maculatum (Acari: Ixodidae). Journal of Medical Entomology 51 (1):119-129.
Mukherjee N, Beati L, Sellers M, Burton L, Adamson SW, Robbins RG, Moore F, Karim S. (2014). Importation of exotic ticks and tick-borne spotted fever group rickettsia into the United States by migrating songbirds. Ticks and Tick-Borne Diseases 5: 127-134.
Adamson SW, Browning RE, Singh P, Nobles S, Villarreal, A, Karim S. (2014). Transcriptional activation of antioxidants may compensate for selenoprotein deficiencies in Amblyomma maculatum (Acari: Ixodidae) injected with selK-or selM-dsRNA. Insect Molecular Biology 2394):497-510.
Huang KF, Hsu HL, Karim S, Wang A. (2014). Structural and functional analysis of a glutaminyl cyclase from Ixodes scapularis reveal a metal-independent catalysis and inhibitor binding. Acta Crystallographica Section D D70, 789-801.
Adamson SW, Browning RE, Chao CC, Bateman R, Ching WM, Karim S. (2013). Molecular characterization of the tick salivary glutaminyl cyclase. Insect Biochemistry and Molecular Biology, 43, 781-793.
Adamson SW, Browning RE, Budachetri K, Ribeiro JMC, Karim S. (2013). Knockdown of Selenocysteine-specific Elongation Factor in Amblyomma maculatum alters the pathogen burden of Rickettsia parkeri with epigenetic control by the Sin3 Histone Deacetylase Corepressor complex. PLoS ONE 8(11): e82012.
Villarreal AM, Adamson SW, Browning RE, Budachetri K, Sajid MS, Karim S. 2013. Molecular characterization and functional significance of the Vti family of SNARE proteins in tick salivary glands. Insect Biochemistry and Molecular Biology 43(5), 483-493.
Browning R, Karim S. 2013. RNA interference-mediated depletion of N-ethylmaleimide Sensitive Fusion Protein and synaptosomal associated protein of 25 kDa results in the inhibition of blood feeding of the Gulf-Coast tick, Amblyomma maculatum. Insect Molecular Biology 22 (3), 245-257.
Karim S, Singh P, Ribeiro JMC. (2011). A deep insight into the sialotranscriptome of the Gulf Coast tick, Amblyomma maculatum. PLoS ONE 6(12): e28525.