In a tradition of academic leadership, Southern Miss has five colleges: the College of Arts and Letters; the College of Business; the College of Education and Psychology; the College of Health; and the College of Science and Technology. Within the five colleges, nearly 50 different academic departments offer a large number of degrees, providing the Southern Miss student with the comprehensive college education expected from the University that promotes the power of learning.

• College of Arts and Letters
• College of Business
• College of Education and Psychology
• College of Health
• College of Science and Technology
• Honors College