Marius H. Brouwer, Ph.D.

Gulf Coast Research Laboratory
703 East Beach Drive
Ocean Springs, MS 39564

Phone: (228) 872-4294

Fax: (228) 872-4204

marius.brouwer@usm.edu

Position:

• Professor - Department of Coastal Sciences, Environmental Biochemistry and Toxicology
• Director Consortium for Estuarine Ecoindicator Research for the Gulf of Mexico (CEER-GOM)
• Adjunct Professor - University of Mississippi, Department of Pharmacology
• Adjunct Professor - Duke University School of the Environment

Education:

• Ph.D. - University of Groningen, The Netherlands, 1975. Biochemistry.
• Drs. Degree - University of Groningen, The Netherlands, 1969. Microbiology and Biochemistry.

Research Interests:

• The main interest of my laboratory centers around the study of (1) the dual role of metals and oxygen as essential and toxic elements in biological systems, and (2) the effects of endocrine disrupting chemicals on estuarine species. Specific research projects address:
• Structure, function, and transcriptional/translational control of proteins involved in detoxification of metals, and in antioxidant defense
• Application of molecular tools for assesment of ecosystem health
• Development of molecular indicators of dissolved oxygen stress in estuarine organisms
• Mechanisms of effects of estrogenic and antiestrogenic chemicals on sex differentiation and reproduction of fish
• All projects use marine organisms as experimental animals.

Discussion of Research Interests

Selected Publications:

• Karels, A.A., Manning, S., Hoexum Brouwer, T., and Brouwer, M. 2003 Reproductive effects of estrogenic and antiestrogenic chemicals on sheepshead minnow (Cyprinodon variegatus). Env. Tox. Chem. 22: 855-865
• Brouwer, Marius., Thea Hoexum Brouwer, Walter Grater and Nancy Brown-Peterson. 2003 Replacement of a cytosolic copper/zinc superoxide dismutase by a novel cytosolic manganese superoxide dismutase in crustaceans that use copper (haemocyanin) for oxygen transport. Biochem. J. 374: 219-28
• Karels, Arthur, A., Brouwer, Marius. 2003 Cloning, sequencing and phylogenetic classification of an estrogen receptor " subtype of sheepshead minnow (Cyprinodon variegatus). Comp. Biochem. Physiol. 135: 263 – 272.
• David R. Geter, John W. Fournie , Marius H. Brouwer, Anthony B. DeAngelo, William E. Hawkins 2003 p -Nitrophenol and glutathione response in medaka (Oryzias latipes) exposed to MX, a drinking water carcinogen. 2003. Comparative Biochemistry and Physiology Part C 134: 353–364
• Marius Brouwer , Patrick Larkin, Nancy Brown-Peterson, Christina King, Steve Manning and Nancy Denslow 2004. Effects of hypoxia on gene and protein expression in the blue crab, Callinectes sapidus Mar Env Research 58 : 787-792
• Niemi, Gerald, Denice Wardrop, Robert Brooks, Susan Anderson, Valerie Brady, Hans Paerl, Chet Rakocinski, Marius Brouwer, Barbara Levinson, Michael McDonald. Rationale for a New Generation of Ecological Indicators for Coastal Waters. 2004 Env. Health Perspect. 112: 979-986.
• Marius Brouwer , Nancy J. Brown-Peterson, Patrick Larkin, Steve Manning, Nancy Denslow and Kenneth Rose. 2005. Molecular and Organismal Indicators of Chronic and Intermittent Hypoxia in Marine Crustacea. Pp. 261-276 in: Estuarine Indicators (Bortone, S. Ed.) CRC Press.
• Nancy J. Brown-Peterson, Patrick Larkin, Nancy Denslow, Christina King, Steve Manning and Marius Brouwer 2005 Molecular Indicators of Hypoxia in Blue Crab, Callinectes sapidus. Mar. Ecol. Progr. Series 286: 203-215
• Adam J. Kuhl, Steve Manning, and Marius Brouwer 2005 Brain Aromatase in Japanese Medaka (Oryzias latipes): Molecular characterization and role in xenoestrogen induced sex reversal. The Journal of Steroid Biochemistry and Molecular Biology 96: In press

Comprehensive Publications List