1995-2001, Ph.D., “Factors involved in the regulated production of smooth muscle gamma actin mRNA,” 
Department of Cell Biology and Neuroscience, University of South Alabama College of Medicine, Mobile, AL; B.S. Cellular & Molecular Biology-Pre-professional; Summa Cum Laude, University of West Florida, Pensacola, FL

1987-1991 High school diploma; Class Valedictorian, Gulf Breeze High School, Gulf Breeze, FL

Molecular mechanisms underlying disease states; signaling cascades involved in disease states; environmental toxins and cancer; inflammatory processes; metastatic cancer progression; extracellular environmental influences on cancer.

Fillmore, R.A., Mitra, A., Shevde, L.A., and Samant, R.S.  2009.  Nmi (N-Myc interactor) inhibits Wnt/b-catenin signaling and retards tumor growth.  Int. J. Cancer. 

Clark, D.W., Mitra, A., Fillmore, R.A., Jiang, W.G., Samant, R.S., Fodstad, O., Shevde, L.A.  2008.  Nupr1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress.  Current Cancer Drug Targets  8(5):421-430.

Zhang, Y., Fillmore, R.A., and Zimmer, W.E.  2008.  Structural and functional analysis of domains mediating interaction between the bagpipe homologue, Nkx3.1 and serum response factor.  Exp. Biol. and Med.  233(3):297-309.

Mitra, A., Fillmore, R.A., Metge, B.J., Mathur, R., Xi, Y., King, J., Ju, J., Pannell, L., Shevde, L.A., Samant, R.S.  2008.  Large isoform of MRJ (DNAJB6) reduces malignant activity of breast cancer cell lines.   Breast Cancer Research 10:R22 (doi:10.1186/bcr1874).

Samant, R.S., Clark, D., Fillmore, R.A., Metge, B.J., Chandramouli, K.H., Chambers, A.F., Casey, G., Welch, D.R., and Shevde, L.A.  2006.  Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-Kappa B activation.  Mol. Cancer.  6:6 (doi:10.1186/1476-4598-6-6).

Ritchie, M.H., Fillmore, R.A., Lausch, R.N., and Oakes, J.E.  2004.  A role for NF-kB binding motifs in the differential induction of chemokine gene expression in human corneal epithelial cells.  Invest. Ophthalm. Vis. Sci.  45:2299-2305.

Fillmore, R.A., Nelson, S.E., Lausch, R.N., and Oakes, J.E.  2003.  Differential regulation of ENA-78 and GCP-2 gene expression in human corneal keratocytes and epithelial cells.  Invest. Ophthalm. Vis. Sci.  44:3432-3437.

Carson, J.A., Culberson, D., Thompson, R., Fillmore, R., and Zimmer, W.  2003.  Smooth muscle g-actin promoter regulation by RhoA and serum response factor signaling.  Biochem. Biophys. Acta.  1628:133-139.

Fillmore, R.A., and Zimmer, W.E.  2002.  The smooth muscle gamma actin gene is androgen-responsive in prostate epithelia.  Gene Expression, 10:201-211.

Fillmore, R.A., and Zimmer, W.E.  2000.  Identification of mRNA encoding homeobox proteins Hox b4 and Hox b5 in developing chicken gizzard tissues.  Cell. & Mol. Biol. Lett.  5:495-509.

Carson, J.A., Fillmore, R.A., Schwartz, R.J., and Zimmer, W.E.  2000.   The smooth muscle g-actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor.  J. Biol. Chem.  275:39061-39072.

Browning, C.L., Culberson, D.E., Aragon, I.V., Fillmore, R.A., Croissant, J.D., Schwartz, R.J., and Zimmer, W.E.  1998.  The developmentally regulated expression of serum response factor plays a key role in the control of smooth muscle-specific genes.  Developmental Biology 194:18-37.