Charles L. McCormick

Professor of Polymer Science

McCormick Group Research Page


BS, Chemistry, Millsaps College , 1968.
PhD, Chemistry, University of Florida, 1973.
Senior Research Chemist, AKZO, 1973-74.
Visiting Professor Cambridge University , Spring 1992.
Visiting Professor Royal Institute of Sweden , Summer 1997. 
Department of Polymer Science, The University of Southern Mississippi

Assistant Professor, 1974-1976

Associate Professor, 1977-1980

Professor, 1981-present
Bennett Distinguished Research Professor of Science, 1997-1999.

Fellow Polymer Division, American Chemical Society, 2012.

Research Areas

Controlled free radical polymerization in aqueous media, Rational design of polymer architecture for nanomedicine, Self-assembly of stimuli-responsive block copolymers, Polymeric surfactants for Oil Spill Remediation, Conjugation and delivery of diagnostic and therapeutic agents, In Situ formation of polymer-stabilized nanoparticles, Associative hydrogel networks for biomedical applications, Targeted cellular delivery of siRNA/polyelectrolyte nanoparticles, Controlled release of bioactive agents.

Representative Publications

DeeDee Smith, Andrew C. Holley, and Charles L. McCormick, “RAFT-Synthesized Copolymers and Conjugates Designed for Therapeutic Delivery of SiRNA,” Polymer Chemistry, 2011, 2 (7), 1428 – 1441.

Nicolas J. Treat, DeeDee Smith, Chengwen Teng, Joel D. Flores, Adam W. York, Faqing Huang, Charles L. McCormick, “Aqueous RAFT Polymerization of Guanidine-Containing Methacrylamide: A Cell Penetrating Peptide Mimic,” ACS Macro Lett., 2012, 1 (1), pp 100–104.

Joel D. Flores, Nicolas J. Treat, Adam W. York, and Charles L. McCormick, “Facile, Modular Transformations of RAFT Block Copolymers via Sequential Isocyanate and Thiol-Ene Reactions,” Polymer Chemistry, 2011, 2, 1976-1985.

Stacey Kirkland-York, Yilin Zhang, Adam E. Smith, Adam W. York, Faqing Huang,Charles L. McCormick, “Tailored Design of Au Nanoparticle-siRNA Carriers utilizing Reversible Addition-Fragmentation Chain Transfer Polymers,” Biomacromolecules, 2010, 11 (4), 1052-1059.

Adam E. Smith, Xuewei Xu, Daniel Savin, Charles L. McCormick, Reversible Gold “Locked” Synthetic Vesicles Derived from Stimuli-Responsive Diblock Copolymers,” Polymer Chemistry, 2010, 1.

Adam York, Faqing Huang, Charles L. McCormick, Rational Design of Targeted Cancer Therapeutics through the Multi-Conjugation of Folate and Cleavable siRNA to RAFT-synthesized (HPMA-s-APMA) Copolymers,” Biomacromolecules, 2010, 11 (2), 505–514.

Adam E. Smith, Xuewei Xu, Daniel Savin, Charles L. McCormick, “‘Schizophrenic’ Self-Assembly of Block Copolymers Synthesized via Aqueous RAFT Polymerization: From Micelles to Vesicles,” Macromolecules, 2010, 43 (3), pp 1210–1217.

Adam E. Smith, Xuewei Xu, and Charles. L. McCormick, “Stimuli-Responsive Amphiphilic (Co)polymers via RAFT Polymerization,” Progress in Polymer Science, 2010, 35, 45–93.

Adam W. York, Yilin Zhang, Andrew C. Holley, Yanlin Guo, Faqing Huang and Charles L. McCormick, “Facile Synthesis of Multivalent Folate-Block Copolymer Conjugates via Aqueous RAFT Polymerization: Targeted Delivery of siRNA and Subsequent Gene Suppression,”  Biomacromolecules, 2009,10(4), 936-943.

Adam E. Smith, Xuewei Xu, Thomas U. Abell, Stacey E. Kirkland, Ryan M. Hensarling and Charles L. McCormick, “Tuning Nanostructure Morphology and Gold Nanoparticle “Locking” of Multiply-Responsive Amphiphilic Diblock Copolymers,” Macromolecules2009, 42(8), 2958-2964.

Joel D. Flores, Xuewei Xu, Nicolas J. Treat and Charles L. McCormick, “Reversible “Self-Locked” Micelles from a Zwitterion-Containing Triblock Copolymer,” Macromolecules20094(14), 4941–4945.

Atsushi Sogabe and Charles L. McCormick, “Reversible Addition-Fragmentation Chain Transfer (RAFT) Polymerization in an Inverse Microemulsion System: Homopolymerizaton and Chain Extension,” Macromolecules, 2009, 42(14), 5043–5052.

Brent S. Sumerlin, Brad S. Lokitz, Jonathan E. Stempka, Charles L. McCormick, “RAFT-Synthesized Diblock and Triblock Copolymers: Thermally-Induced Supramolecular Assembly in Aqueous Media,” Soft Matter2008, 4, 1760-1773.

Adam W. York, Stacey E. Kirkland, Charles L. McCormick, “Advances in the Synthesis of Amphiphilic Block Copolymers via RAFT Polymerization: Stimuli-Responsive Drug and Gene Delivery,” Advanced Drug Delivery Review, 2008, 60(9), 1018-1036.

Stacey E. Kirkland, Ryan M. Hensarling, Shawn D. McConaughy, William L. Jarrett and Charles L. McCormick, “Thermoreversible Hydrogels from RAFT-Synthesized BAB Triblock Copolymers: Steps Toward Biomimetic Matrices for Tissue Regeneration,” Biomacromolecules, 2008, 9, 472-480.

Andrew B. Lowe and Charles L. McCormick, “Reversible Addition-Fragmentation Chain Transfer (RAFT) Radical Polymerization and the Synthesis of Water-Soluble (Co)Polymers in Homogeneous Organic and Aqueous Media,” Progress in Polymer Science 32, 2007,283-351.

C.L. McCormick and A.B. Lowe,“Recent Developments in Synthesis of Functional Water-Soluble Copolymers with Controlled Structures,” Accounts of Chemical Research 37, 2004, 312-325.

A.B. Lowe and C.L. McCormick, “Synthesis and Solution Properties of Zwitterionic (Co)Polymers,” Chemical Reviews2002, 102[11], 4177-4190.