Daniel Savin, Ph.D.

Assistant Professor, School of Polymers and High Performance Materials

The research in the Savin group is largely associated with the applications of self-assembled polymers and block copolymers, with particular emphasis on solution characterization and property-structure relationships. The research projects can be broken into three broad categories: (1) Bio-inspired, responsive materials as drug delivery vehicles, (2) Energy absorbing nanocomposites and foams, and (3) Polymers for environmental remediation.  Our principal analytical tools are dynamic light scattering and rheology, although we invoke most polymer solution characterization techniques. We also rely heavily on microscopy (TEM and AFM) and mechanical testing (DMA, Instron, Dynatup).  Undergraduate students in my group gain experience in both synthesis and advanced characterization techniques.

Prof. Savin is the Director of the summer Research Experience for Undergraduates program for the School of Polymers, and is co-Director of the U.S.-India International Research Experience for Students in Self-Assembling Stimuli-Responsive, Biomimetic Polymers.  In five years at USM, I have hosted nine USM undergraduate students and 12 summer REU participants.

 Publications:

(# Indicates undergraduate student co-author)

 O. McNair, A. Janisse, D. Krzeminski, #D. Brent, T. Gould, J. Rawlins, D. Savin.  “Impact Properties of Thiol-Ene Networks.” ACS Appl. Mat. Int. 2014. (In Press DOI: 10.1021/am403238g)

 W-M. Wan, P. Pickett, D. Savin, C. McCormick.  “Structurally Controlled "Polysoaps” via RAFT Copolymerization of AMPS and Dodecyl Acrylamide for Environmental Remediation.”  Polym. Chem. 2014.  (In Press DOI: 10.1039/c3py01073b)

 A. Holley, J. Ray, W. Wan, D. Savin, C. McCormick.  “Endolytic, pH-Responsive HPMA-b-(L-Glu) Copolymers Synthesized via Sequential Aqueous RAFT and Ring Opening Polymerizations.” Biomacromolecules 2013. (In Press, DOI:10.1021/bm401205y)

 O. McNair, B. Sparks, A. Janisse, #D. Brent, D. Patton, D. Savin.  “Highly Tunable Thiol-Ene Networks via Dual Thiol Addition.” Macromolecules 2013. 46 (14), p. 5614-5621.

 L. Paslay,#L. Falgout,D. Savin,S. Heinhorst, G. Cannon, S. Morgan.  “Kinetics and Control of Self-Assembly of ABH1 Hydrophobin from the Edible White Button Mushroom.”  Biomacromolecules 2013. 14 (7), p. 2283-2293.

 A. Bapat, J. Ray, D. Savin, B. Sumerlin.  “Redox-Responsive Dynamic-Covalent Assemblies: Stars and Miktoarm Stars.” Macromolecules 2013. 46 (6): p 2188–2198.

 J. Ray, A. Johnson, D. Savin.  “Self-assembly and Responsiveness of Polypeptide-based Block Copolymers: How “Smart” Behavior and Topological Complexity Yield Unique Assembly in Aqueous Media.”  J. Polym. Sci., Part B: Polym. Phys. 2013.  51(7): p. 508-523.

 A. Bapat, J. Ray, D. Savin, E. Hoff, D. Patton, B. Sumerlin.  “Dynamic-covalent Nanostructures Prepared by Diels–Alder Reactions of Styrene-maleic anhydride-derived Copolymers Obtained by One-step Cascade Block Copolymerization.”  Polym. Chem. 2012.  3(11): p. 3112-3120.

 J. Ray, S. Naik, E. Hoff, A. Johnson, #J. Ly, #C. Easterling, D. Patton, D. Savin.  “Stimuli-responsive Peptide-based ABA Triblock Copolymers:  Unique Morphology Transitions with pH.”  Macromol Rapid Commun. 2012. 33(9): p. 819-826.  Featured on the Front Cover of the issue.  In Top 10 most accessed April 2012.

 B. Sparks, #T. Kuchera, M. Jungman, A. Richardson, D. Savin, S. Hait, J. Lichtenhan, M. Striegel, D. Patton.  “Cyclic Tetravinylsiloxanetetraols as Hybrid Inorganic-Organic Thiol-Ene Networks.”  J. Mat. Chem. 2012. 22(9): p. 3817-3824.

 R. Griffitt, N. Brown-Peterson, C. Manning, D. Savin, I. Boube, R. Ryan, M. Brouwer. “Effects of Chronic Nanoparticulate Silver Exposure to Adult and Juvenile Sheepshead Minnow (Cyprinodon variegatus).” Environmental Toxicology and Chem. 2012, 31, 160-167.

 A. Bapat, D. Roy, J. Ray, D. Savin, B. Sumerlin. “Dynamic-Covalent Macromolecular Stars with Boronic Ester Linkages.” J. Am. Chem. Soc. 2011, 133, 19832–19838.

 S. Naik, J. Ray, D. Savin. "Temperature- and pH-Responsive Self-assembly of Poly(propylene oxide)-b-Poly(lysine) Block Copolymers in Aqueous Solution" Langmuir 2011, 27, 7231–7240.

 J. Ray, #J. Ly, D. Savin. “Peptide-based Lipid Mimetics with Tunable Core Properties via Thiol-Alkyne Chemistry .” Polym. Chem. 2011, 2, 1536-1541. In Top 10 most downloaded March 2011.

 B. Sparks, J. Ray, D. Savin, C. Stafford, D. Patton. "Synthesis of Thiol-clickable and Block Copolypeptide Brushes via Nickel-mediated Surface Initiated Polymerization of a-Amino Acid N-carboxyanhydrides (NCAs)." Chem. Commun. 2011, 47, 6245-6247.

 S. Naik, J. Chan, C. Comer, C. Hoyle, D. Savin.  “Thiol–yne ‘Click’ Chemistry as a Route to Functional Lipid Mimetics.” Polym. Chem. 2011. 2, 303-305.  Invited to Polymer Chemistry ‘Emerging Investigators” issue.   Featured as a “Hot Article” in Polymer Chemistry blog.

 A. Smith, X. Xu, D. Savin, C. McCormick.  “Reversible Gold Locked Synthetic Vesicles Derived from Stimuli-Responsive Diblock Copolymers.” Polym. Chem. 20101, 628-630.

 A. Smith, X. Xu, S. Kirkland-York, D. Savin, C. McCormick. "Schizophrenic” Self-Assembly of Block Copolymers Synthesized via Aqueous RAFT Polymerization: From Micelles to Vesicles." Macromolecules 2010. 43 (3), 1210-1217.

 A. Magenau, N. Martinez-Castro, D. Savin, R. Storey.  “Site Transformation of Polyisobutylene Chain Ends to RAFT Polymerization: Synthesis of Poly(isobutylene-b-N-isopropylacrylamide).” Macromolecules 2009.  42 (21), 8044-8051.

 S. Naik, D. Savin. “Poly(Z-Lysine)-based Organogels: Effect of Interfacial Frustration on Gel Strength.” Macromolecules 2009, 42 (18), 7114–7121.