Yanlin Guo, Ph.D.
Associate Professor, Depatment of Biological Sciences
The research in Dr. Yanlin Guo’s laboratory focuses on the study of the molecular and cellular mechanisms that control cardiovascular development. Embryonic stem cells (ESCs) have an unlimited capacity for self-renewal and can be induced to become different cell types, such as endothelial cells for engineering blood vessels. Therefore, ESCs are considered to be a promising source for tissue engineering and regenerative medicine. However, we have recently found that endothelial cells differentiated from mouse ESCs by conventional methods are not fully functional; in particular, they do not have innate immunity to a wide range of infectious agents and cytokines. This finding raises a serious concern for applications of ESC-derived cells in regenerative medicine. Using mouse ESCs as a model system, we have been developing an mRNA-directed differentiation method that is incorporated with immunostimulation, with the expectation that this strategy could effectively generate functional endothelial cells with competent innate immunity, therefore suitable for vascular tissue engineering. Students in the laboratory will gain advanced knowledge in stem cell biology and research experience in cell culture, cellular, molecular, and biochemical techniques essential for basic and medical research.