The University of Southern Mississippi Alumni Association offers two chapters in the south Mississippi area. On the Gulf Coast, the Gulf Coast Metro Chapter is based in the southernmost counties of Mississippi. This chapter holds a variety of events, including the annual Gulf Coast Beach Bash. Each event is designed to help raise money for scholarships for students from the Gulf Coast to attend Southern Miss and to facilitate increased involvement in alumni activities.

The Southeast Mississippi chapter is based in Jackson and George counties and their goals are to play an active role in recruiting new students to Southern Miss, provide scholarships to deserving area students, to provide social functions for alumni, friends and supporters of Southern Miss, to keep area alumni informed on the status of the University, to be an active member in community service on the Mississippi coastal area, and to promote Southern Miss as much as possible.