David Echevarria, Ph.D.

Associate Professor, Department of Psychology

Our laboratory focuses on the application of zebrafish behavior models to better understand stress-induced changes in physiology and behavior. Specifically, we are interested in how “classical” neurotransmitter systems (e.g., noradrenergic, dopaminergic and serotonergic systems) function during normal, intoxicated and stressed states to influence physiology and behavior. We also investigate the accompanying changes in the production of glucocorticoids (i.e., cortisol).

Additionally, we are interested in social behavior and understanding individual differences in behavior. Individual variation in behavior is more than just noise around an average of optimum behavioral responses. When the environment is the same, individuals consistently act differently from each other, which has consequences in many aspects of an individual’s life, including: mate choice selection, response to predators, exploring new environments, among many others which ultimately influences fitness. In human research, the idea of consistent individual differences in behavior over time and across contexts is synonymous with personality. Although identifying “personality” in animals is not a straightforward process, this working definition can be a starting point for investigation.

Journal Articles

Dufrene, B.A., Watson, T.S., Echevarria, D.J., Weaver, A.D. (In Press). Idiographic effects of tic-related conversation on the rate of vocal and motor tics in two siblings. Journal of Obsessive-Compulsive and Related Disorders.

Collier, A.D., Echevarria, D.J. (In Press). The utility of the zebrafish model in conditioned place preference to assess the rewarding effects of drugs. Behavioural Pharmacology. (Invited Submission).

Kalueff AV, Gebhardt, M, Stewart, AM, Cachat, JM, Brimmer, M, Chawla, JS, Craddock,C, Kyza, EJ, Roth, A, Landsman, S, Gaikwad, S, Robinson, K, Baatrup, E, Tierney, K, Shamchuk, A, Norton, W, Miller, N, Nicolson, T, Braubach, O, Gilman, CP, Pittman, J, Rosemberg, DB, Gerlai, R, Echevarria, D, Lamb, E, Neuhauss, SCF, Weng, David J. Echevarria, Ph.D. 4 W, Bally-Cuif, L, Schneider, H. (2013). Towards a comprehensive catalog of zebrafish
behavior 1.0, and beyond. Zebrafish. (In Press).

Lamb, E.A., Echevarria, D.J., Jouandot, D.J. (2012). The utility of the T-Maze in assessing learning, memory, and models of neurological disorders in the zebrafish. Behaviour, 149, 1081.1097.

Echevarria, D.J., Jouandot, D.J., Toms, C.N. (2011). Assessing attention in the zebrafish. Are we there yet? Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1; 35 (6), 1416-1420.

Echevarria, D.J., Toms, C.N., Jouandot, D.J. (2011). Alcohol induced behavior changes in zebrafish models. Invited submission, Reviews in the Neurosciences, 22(1), 85-93.

Echevarria, D.J., Hammack, C.M., Jouandot, D.J., Toms, C.N. (2010). Does acute alcohol exposure modulate aggressive behaviors in the zebrafish (Danio Rerio), or is the bark worse that the bite? International Journal of Comparative Psychology, 23, 62-69.

Toms, C., Echevarria, D.J., Jouandot, D.J. (2010). A methodological review of personality-related studies in fish; focus on the shy-bold axis of behavior. International Journal of Comparative Psychology, 23, 1-25.

McCloskey, M.S., Berman, M.E., Echevarria D.J., Coccaro, E.F. (2009). Effects of acute alcohol intoxication and paroxetine on aggression in men. Alcoholism: Clinical and Experimental Research. 33 (1), 1-10. 2 citations.

Echevarria, D.J., Hammack, C.M., Pratt, D.W., Hosemann, J.D. (2008). A novel test battery to assess global drug effects using the zebrafish. International Journal of Comparative Psychology, 21, 19-34.

Morilak, D.A., Barrera, G., Echevarria, D.J., Garcia, A.S., Hernandez, A., Ma, S., Petre, C.O. (2005) Role of brain norepinephrine in the behavioral response to stress. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29, 1214-1224. 90 citations.

Echevarria, D.J., Hernandez, A., Diogenes, A., Morilak, D.A. (2005). Administration of the galanin antagonist M40 in the lateral septum attenuates shock-probe/defensive burying behavior in rats. Neuropeptides, 39 (5), 445-451. 12 citations.

Brewer, A., Echevarria, D.J., Langel, Ü, Robinson, J.K. (2005). Assessment of new functional roles for galanin in the CNS. Neuropeptides, 39 (3), 323-326. 10 citations.

David J. Echevarria, Ph.D. Barrera, G., Echevarria, D.J., Poulin, J.F., Laforest, S., Drolet, G., & Morilak, D.A. (2005). One for all or one for one: does co-transmission unify the concept of a brain galanin “system” or clarify any consistent role in anxiety? Neuropeptides, 39 (3), 289-292. 15 citations.

Echevarria, D.J., Brewer, A., Bushell, G., Manuzon, H., Langel, Ü., & Robinson, J.K. (2005). Galanin and perseveration. Brain Research, 1041 (2), 143-148. 2 citations.

Riha, P.D., Bruchey, A.K., Echevarria, D.J., & F. Gonzalez-Lima. (2005). Facilitation of memory by methylene blue: dose-dependent effects on behavior and brain oxygen consumption. European Journal of Pharmacology, 511 (2-3), 151-158. 13 citations.

Echevarria, D.J., Brewer, A., Burk, J.A., Brown, S.N., Manuzon, H., & Robinson, J.K. (2005). Construct validity of an operant signal detection task for rats. Behavioural Brain Research, 157 (2), 283-290. 7 citations.

Abramov, U, Floren, A, Echevarria, D.J., Brewer, A., Manuzon, H., Robinson, J.K., Bartfai, T., Vasar. E., & Langel, Ü. (2004). Regulation of feeding by galnon. Neuropeptides, 38(1), 55-61. (Top 10 cited article in Neuropeptides 2004). 10 citations.