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Fengwei Bai

Dr. Fengwei Bai



Dr. Bai received his Ph.D. in Genetics from Fudan University and did his postdoctoral training at Yale University School of Medicine. Dr. Bai's research interests are to understand how viruses are recognized by the host’s innate immune system and how innate immunity initiates and generates protective adaptive immunity. His long-term research goal is to use this knowledge in the rational design of effective vaccines or therapeutics for the prevention of the transmission of viral pathogens. Dr. Bai’s research is funded by NIH and various research foundations. For a detailed publication list, please visit:
In addition, Dr. Bai is managing the USDA-certified Biosafety-Level 3 (BSL3) cell culture and animal research facilities, and collaborations from academia and industry are welcome!

  • PHD - Fudan University (2002)
  • MS - Ocean University of China (1999)

BSC486/586 Immunology
BSC484/584 Virology
BSC485/585 Viral Pathogenesis and Diagnosis

  • An effective live-attenuated Zika vaccine candidate with a modified 5' untranslated region, NPJ Vaccines, 2023, 10.1038/s41541-023-00650-w
  • Book: West Nile virus - Methods and Protocols, 2023,
  • A Dual-Approach Strategy to Optimize the Safety and Efficacy of Anti-Zika Virus Monoclonal Antibody Therapeutics, Viruses, 2023, 10.3390/v15051156
  • Mouse trophoblast cells can provide interferon-based antiviral protection to embryonic stem cells via paracrine signaling, Journal of Immunology, 2022, 10.4049/jimmunol.2100679
  • Murine Trophoblast Stem Cells and Their Differentiated Cells Attenuate Zika Virus In Vitro by Reducing Glycosylation of the Viral Envelope Protein, Cells, 2021, 10.3390/cells10113085
  • Interleukin-17A Facilitates Chikungunya Virus Infection by Inhibiting IFN-α2 Expression, Front Immunol., 2020, 10.3389/fimmu.2020.588382
  • Zika virus infection causes widespread damage to the inner ear., Hearing Research, 2020, 10.1016/j.heares.2020.108000
  • In vitro and in vivo efficacy of anti-chikungunya virus monoclonal antibodies produced in wild-type and glycoengineered Nicotiana benthamiana plants., Plant Biotechnol J, 2019, 10.1111/pbi.13194
  • Congenital Zika Virus Infection in Immunocompetent Mice Causes Postnatal Growth Impediment and Neurobehavioral Deficits., Frontiers in microbiology, 2018, 10.3389/fmicb.2018.02028
  • Exosomes serve as novel modes of tick-borne flavivirus transmission from arthropod to human cells and facilitates dissemination of viral RNA and proteins to the vertebrate neuronal cells., PLoS pathogens, 2018, 10.1371/journal.ppat.1006764
  • American Society of Microbiology
  • American Heart Association
  • The American Association of Immunologists
  • English (Full Professional)
  • Chinese (Native or Bilingual)

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Areas of Expertise

Virology, Immunology, Infectious Diseases, Cell and Molecular Biology