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Alex Flynt

Dr. Alex Flynt

Associate Professor


Research in my lab broadly investigates the role of RNA biology in post-transcriptional gene regulation with a major focus on the biogenesis and function of non-coding, small regulatory RNAs. These molecules are most famously known as the effectors of RNAi and have pervasive roles in negative regulation of gene expression and defense against invasive genetic elements (i.e. viruses and transposons).

  • PHD - Vanderbilt University (2007)
  • BS - Austin Peay State University (2001)

Developmental Biology

  • Rewired RNAi-mediated genome surveillance in house dust mites, PLOS GENETICS, 2018, 10.1371/journal.pgen.1007183
  • siRNAs and piRNAs collaborate for transposon control in the two-spotted spider mite, RNA, 2018, 10.1261/rna.065839.118
  • Guanidinium-Functionalized Interpolyelectrolyte Complexes Enabling RNAi in Resistant Insect Pests, BIOMACROMOLECULES, 2018, 10.1021/acs.biomac.7b01717
  • Deep experimental profiling of microRNA diversity, deployment, and evolution across the Drosophila genus, GENOME RESEARCH, 2018, 10.1101/gr.226068.117
  • The Neuroprotective role of miR-1017, a 3 ' Tailed Mirtron, FASEB JOURNAL, 2017
  • Utilizing intrinsic properties of polyaniline to detect nucleic acid hybridization through UV-enhanced electrostatic interaction, Biomacromolecules, 2015, 10.1021/acs.biomac.5b00935
  • Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines, GENOME RESEARCH, 2014, 10.1101/gr.161554.113
  • The impact of age, biogenesis, and genomic clustering on Drosophila microRNA evolution, RNA, 2013, 10.1261/rna.039248.113
  • Discovery of hundreds of mirtrons in mouse and human small RNA data, GENOME RESEARCH, 2012, 10.1101/gr.133553.111
  • MicroRNA Biogenesis via Splicing and Exosome-Mediated Trimming in Drosophila, MOLECULAR CELL, 2010, 10.1016/j.molcel.2010.06.014
  • English (Native or Bilingual)

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Areas of Expertise

RNA biology, Genomics, Computational Biology