Immunology: BSC 486/586
Virology: BSC 484/584
Viral Pathogenesis and Diagnosis: BSC 485/585
My research interests are to understand how viruses are recognized by the host’s innate immune system and how innate immunity initiates and generates protective adaptive immunity. My long-term research goal is to use this knowledge in rational design of effective vaccines or therapeutics, or of microbicides for the prevention of transmission of viral pathogens. Currently, the research in my laboratory centers on study of the pathogenesis of mosquito-transmitted flaviviruses and alphaviruses, such as West Nile virus, Zika virus, dengue virus and chikungunya virus, and development of novel diagnostic methods and antivirals.
D'Angelo W, Acharya D, Wang R, Wang J, Gurung C, Chen B, Bai F, Guo YL., Development of antiviral innate immunity during In vitro differentiation of mouse embryonic stem cells., Stem Cells Dev. 2016 Apr 15;25(8):648-59.
Acharya D, Paul AM, Anderson JF, Huang F, Bai F., Loss of glycosaminoglycan receptor binding after mosquito cell passage reduces chikungunya virus infectivity., PLoS Negl Trop Dis. 2015 Oct 20;9 (10):e0004139.
Paul A M, Fan Z., Sinha SS, Shi Y, Le L, Bai F, and Ray PC., Bioconjugated gold nanoparticle based SERS probe for ultrasensitive identification of mosquito-borne viruses using Raman fingerprinting, Phys. Chem. C, 2015, 119 (41), pp 23669–23675.
Paul AM, Shi Y, Acharya D, Douglas JR, Cooley A, Anderson JF, Huang F, Bai F., Delivery of antiviral small interfering RNA with gold nanoparticles inhibits dengue virus infection in vitro., J Gen Virol. 2014 Aug; 95(Pt 8):1712-22.
Wang R, Wang J, Paul AM, Acharya D, Bai F, Huang F, Guo YL., Mouse embryonic stem cells are deficient in type I interferon expression in response to viral infections and double-stranded RNA., J Biol Chem. 2013 May 31;288(22):15926-36.
Bai F, Asojo OA, Cirillo P, Ciustea M, Ledizet M, Aristoff PA, Leng L, Koski RA, Powell TJ, Bucala R, Anthony KG., A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF)., J Biol Chem. 2012 Aug 31;287(36):30653-63.
Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E., IL-22 signaling contributes to West Nile encephalitis pathogenesis., PLoS One. 2012;7(8):e44153.
Bai F, Kong KF, Dai J, Qian F, Zhang L, Brown CR, Fikrig E, Montgomery RR., A paradoxical role for neutrophils in the pathogenesis of West Nile virus., J Infect Dis. 2010 Dec 15;202(12):1804-12.
Bai F, Town T, Qian F, Wang P, Kamanaka M, Connolly TM, Gate D, Montgomery RR, Flavell RA, Fikrig E., IL-10 signaling blockade controls murine West Nile virus infection., PLoS Pathog. 2009 Oct;5(10):e1000610.
Town T, Bai F, Wang T, Kaplan AT, Qian F, Montgomery RR, Anderson JF, Flavell RA, Fikrig E., Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing., Immunity. 2009 Feb 20;30(2):242-53.
Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E., Antiviral peptides targeting the West Nile virus envelope protein., J Virol. 2007 Feb;81(4):2047-55.
Bai F, Wang T, Pal U, Bao F, Gould LH, Fikrig E., Use of RNA interference to prevent lethal murine West Nile virus infection., J Infect Dis. 2005 Apr 1;191(7):1148-54.
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