The Office for Disability Accommodations (ODA) is Southern Miss's designated office to verify students' eligibility for accommodations under the Americans with Disabilities Act (ADA). ODA works with eligible students on an individual basis in developing and coordinating plans for the provision of reasonable accommodations that are specific to their disabilities.

In accordance with the Rehabilitation Act of 1973 and the American with Disabilities Act (1990), Southern Mississippi is committed to providing equal access for persons with disabilities and prohibits discrimination on the basis of disability in the admission or access to, or treatment or employment in programs or activities. ODA interacts with all offices and departments on campus to ensure that students with disabilities have full access to, and participation in, university activities. ODA strives to create a positive campus environment where students with disabilities are encouraged to pursue careers on the basis of personal interest and ability.