Associate Professor and Associate Chair
- B.S Chemistry; The University of Arkansas (1995)
- Ph.D. Organic; The University of Oklahoma (1999)
- Post doc.; Vanderbilt University (2000-2003)
- Enzymes in Organic Synthesis
- Unnatural Amino Acid Syntheses
- Mass Spectrometry
- Free Radical Chemistry
Our research focuses on developing synthetic methodologies which exploit enzymes as catalysts to provide the chiral building blocks needed to construct unnatural amino acids, mass spectrometry, and free radical-promoted reactions.
- Synthesis of unnatural amino acids using enzymatic processes
- Incorporation of unnatural amino acids into biologically active peptides (e.g. Somatostatin-14) in order to improve biological activities and improve resistance toward proteolytic degradation
- Developing reagents to modify proteins and peptides at specific residues which can promote the selective fragmentation of the protein/peptide at the modified residue location.
- Synthesis of 15N-labeled compounds by a novel free radicalazidation process
- Almary Chacon, Douglas S. Masterson, Huiyong Yin, Daniel C. Liebler, and Ned A. Porter, “N-Terminal Amino Acid Side-Chain Cleavage of Chemically Modified Peptides in the Gas Phase: A Mass Spectrometry Technique for N-Terminus Identification.” Bioorganic & Medicinal Chemistry 2006, 14, 6213-6222.
- Douglas S. Masterson and Ned A. Porter, “Mechanism of β-Silyl Diacyl Peroxide Decomposition: A Mild and Stereoselective Synthesis of β-Silyl Esters.” The Journal of Organic Chemistry 2004, 69, 3693-3699.
- Douglas S. Masterson, Huiyong Yin, Almary Chacon, David L. Hachey, Jeremy L. Norris, and Ned A. Porter, “Lysine Peroxycarbamates: Free Radical-Promoted Peptide Cleavage.” Journal of the American Chemical Society 2004, 126, 720-721.
- Douglas S. Masterson and Ned A. Porter, “Diastereoselective Free Radical Halogenation, Azidation, and Thiopyridyl Rearrangement of β-Silyl Barton-Esters.” Organic Letters
2002, 4, 4253-4256.